From Logan Airport:
When leaving the airport, follow signs for the Ted Williams Tunnel, I-90 west. Go through the tunnel and follow signs onto the Mass Pike (I-90) west. Stay on the Mass Pike west to Exit 15. At Exit 15, follow signs for I-95/128 North. Take 95/128 North to Exit 31A for Routes 4 and 225 toward Lexington. Continue on Route 4/225 which becomes Bedford Street and then Massachusetts Avenue. In Lexington center, turn left at Edison Way which turns to the left and becomes Depot Place.

From the North via I-93:
Take I-93 South to I-95/128 South. Take 95/128 South to Exit 31A for Routes 4 and 225 toward Lexington. Continue on Route 4/225 which becomes Bedford Street and then Massachusetts Avenue. In Lexington center, turn left at Edison Way which turns to the left and becomes Depot Place.

From the North via I-95 (Rt 128):
Take 95/128 South to Exit 31A for Routes 4 and 225 toward Lexington. Continue on Route 4/225 which becomes Bedford Street and then Massachusetts Avenue. In Lexington center, turn left at Edison Way which turns to the left and becomes Depot Place.

From Route 2:

Take Route 2 to I-95/128 North. Take 95/128 North to Exit 31A for Routes 4 and 225 toward Lexington. Continue on Route 4/225 which becomes Bedford Street and then Massachusetts Avenue. In Lexington center, turn left at Edison Way which turns to the left and becomes Depot Place.

From the South via I-95 (Route 128):
Take 95/128 North to Exit 31A for Routes 4 and 225 toward Lexington. Continue on Route 4/225 which becomes Bedford Street and then Massachusetts Avenue. In Lexington center, turn left at Edison Way which turns to the left and becomes Depot Place.

From West via the Massachusetts Turnpike:
Follow the Turnpike (Route 90) East to Exit 14. After the toll follow signs to I-95/128. Take 95/128 North to Exit 31A for Routes 4 and 225 toward Lexington. Continue on Route 4/225 which becomes Bedford Street and then Massachusetts Avenue. In Lexington center, turn left at Edison Way which turns to the left and becomes Depot Place.